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Also, a lot of effectively established adverse prognostic markers, including U-CLL, ATM aberrations or NOTCH1/BIRC3 mutations, shed their negative outcome in people addressed with VO. The only real component that remained predictive of the shorter progression-cost-free survival Within this cohort of people was TP53 aberrations.112 Last but not least, the alternative BTK inhibitor acalabrutinib was not long ago accepted by the FDA (not with the EMA however) as frontline therapy in watch of the results of the section III trial comparing acalabrutinib vs . ClbO.114
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